黄楚森

发布者:信息发布员发布时间:2022-10-21浏览次数:2163


1. 个人简介:

姓名:黄楚森

职称:教授

邮箱:huangcs@shnu.edu.cn

简介:主要从事精细化工领域中的高性能有机荧光染料研究。围绕功能性荧光染料及其生物医学应用这一研究方向,针对活细胞内分子事件实时跟踪、公共安全和重大疾病诊疗精准测量的实际需求,聚焦于生物检测用功能染料的高选择性、定量检测、多功能识别等关键科学问题,开展了系统的基础研究,发展了系列高性能的荧光探针分子。近年来,以第一作者或通讯作者身份发表SCI论文32篇,包括Chem. Soc. Rev.Coord. Chem. Rev.J. Am. Chem. Soc.Angew. Chem. Int. Ed.Biosens. Bioelectron.Anal. Chem.Ind. Eng. Chem. Res.等期刊。获授权中国发明专利11项,以第一发明人申请中国专利7项,授权4项。

2. 教育工作经历:

教育经历:

 2006.09-2012.06,博士,华东理工大学

 2002.09-2006.06学士,浙江工业大学

工作经历:

 2012.09-至今,澳门沙金在线平台  化学系,讲师/副教授/教授

 2017.03-2019.11Jacobs University Bremen博士后(洪堡学者)

3. 研究领域

 [1]  有机功能染料

 [2]  荧光传感及生物医学检测

 [3]  超分子识别

4. 项目与荣誉

代表性项目

  • 蛋白质相邻巯基动态成像和定量检测及其在炎症和肿瘤微环境检测应用研究,国家自然科学基金(面上项目)2017.01-2020.12

  • 多功能超分子闭锁系统在相邻巯基蛋白的可视化分离应用,上海市青年科技启明星计划A类,2019.04-2022.03

  • 高选择性细胞表面蛋白质相邻巯基荧光探针的设计、合成与原位荧光成像研究,国家自然科学青年基金,2014.01-2016.12

  • 近红外比值型高碘酸根荧光探针的设计、合成及应用,上海市晨光计划,2015.01-2017.12

所获荣誉

德国洪堡学者2017-2019

上海市优秀博士毕业论文2015

5. 成果

代表性论文:

  1. Luling Wu, Jihong Liu, Xue TianRobin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, Hai-Hao Han*, Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang*, Chusen Huang*, Yi Zang, Jia Li, Xiao-Peng He, Ping Li*, Bo Tang, Tony D. James*, and Jonathan L. Sessler*,Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5-triphosphate in Cellular Applications, J. Am. Chem. Soc. 2022, 144, 174-183.

  2. Shuang He, Pei Zhang, Jing Sun, Yu Ji, Chusen Huang*, and Nengqin Jia*, Integrating potential-resolved electrochemiluminescence with molecularly imprinting immunoassay for simultaneous detection of dual acute myocardial infarction markers, Biosens. Bioelectron.2022, 201, 113962.

  3. Huan Li, Chengcheng Wang, Lei Cai, Xiang Yu, Luling Wu*, Nannan Yuan, Yiming Zhu, Nengqin Jia, Tony D. James*, and Chusen Huang*, Versatile Ratiometric Fluorescent Probe Based on the Two-Isophorone Fluorophore for Sensing Nitroxyl, Ind. Eng. Chem. Res.2021, 60, 15913-15920.

  4. Xiaoqin Wei, Tongxia Jin, Chusen Huang*, Nengqing Jia, Weiping Zhu*, Yufang Xu, Xuhong Qian, Monoarsenical-based chemical approaches for exploration of endogenous vicinal-dithiol-containing proteins (VDPs): From the design to their biological application, Coord. Chem. Rev. 2020, 429, 213621.

  5. Luling Wu, Chusen Huang*, Ben P. Emery, Adam C. Sedgwick, Steven D. Bull, Xiao-Peng He, He Tian*, Juyoung Yoon*, Jonathan L. Sessler* and Tony D. James*, Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents. Chem. Soc. Rev. 2020, 49, 5110-5139.

  6. Luling Wu, Yang Wang, Tony D. James*, Nengqin Jia* and Chusen Huang*. A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells, Chem. Commun. 2018, 54, 5518-5521.

  7. Luling Wu, Xiaolin Li, Yifei Ling, Chusen Huang*, and Nengqin Jia*. Morpholine Derivative-Functionalized Carbon Dots-Based Fluorescent Probe for Highly Selective Lysosomal Imaging in Living Cells, ACS Appl. Mater. Interfaces20179, 28222-28232.

  8. Luling Wu, Xiaolin Li, Chusen Huang*, and Nengqin Jia*. Dual-Modal Colorimetric/Fluorescence Molecular Probe for Ratiometric Sensing of pH and Its Application, Anal. Chem.2016, 88, 8332-8338.

  9. Ti Jia, Congying Fu, Chusen Huang*, Haotian Yang, and Nengqin Jia*. A Highly Sensitive Naphthalimide-Based Fluorescence Polarization Probe for Detecting Cancer Cells. ACS Appl. Mater. Interfaces 20157, 10013–10021.

  10. Chusen Huang, Ti Jia, Mengfang Tang, Qin Yin, Weiping Zhu*, Chao Zhang, Yi Yang, Nengqin Jia*, Yufang Xu*, Xuhong Qian. Selective and Ratiometric Fluorescent Trapping and Quantification of Protein Vicinal Dithiols and in Situ Dynamic Tracing in Living Cells,J. Am. Chem. Soc. 2014, 136, 14237-14246.

  11. Chusen Huang*, Ti Jia, Congjun Yu, Amin Zhang and Nengqin Jia*. An ESIPT based fluorescent probe for highly selective and ratiometric detection of periodate, Biosens. Bioelectron. 2015, 63, 513-518.

  12.  Tiantian Chen, Liyan Yin, Chusen Huang*, Yiqiao Qin, Weiping Zhu*, Yufang Xu, and Xuhong Qian, Highly selective “Off–On” fluorescent probe for histidine and its imaging in living cells, Biosens. Bioelectron.2015, 66, 259-265.  

  13. Chusen Huang, Qin Yin, Weiping Zhu*, Yi Yang*, Xin Wang, Xuhong Qian, and Yufang Xu*. Highly Selective Fluorescent Probe for Vicinal Dithiol-Containing Proteins and In-Situ Imaging in Living Cells, Angew. Chem. Int. Ed.2011, 50, 7551- 7556.


代表性授权专利:

1. 一种新型双发射荧光染料探针及其制备与应用,专利号:201811438300.2, 授权日期: 2021.05.18黄楚森,王成成,贾能勤,王冠扬。

2. 基于小分子荧光探针的新型荧光偏振传感器构建及其应用,专利号:201410746656.8, 授权日期:2019.10.29黄楚森,贾倜,贾能勤,付聪颖。

3. 一种检测高碘酸根的高选择性比值型荧光探针,专利号:201410318109.X, 授权日期:2019.09.06黄楚森,贾能勤,贾倜,于丛军,章阿敏。

4. 一种比率型pH荧光探针及其制备方法与应用,专利号:201610142707.5, 授权日期:2019.03.01黄楚森,吴庐陵,贾能勤,贾倜。



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